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KMID : 0624620230560040209
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BMB Reports
2023 Volume.56 No. 4 p.209 ~ p.215
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The role of diuretic hormones (DHs) and their receptors in Drosophila
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Lee Gah-bien
Jang Hee-Jin
Oh Yang-Kyun
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Abstract
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Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrientsensing, and CO2-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems.
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KEYWORD
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DH31, DH31 receptor, DH44, DH44 receptors, Drosophila, Feeding, Fluid secretion, Nutrient sensing, Sleep:wake cycle
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